The formation of vascular networks in vitro develops along two rather distinct stages: during the early migration-dominated stage the main features of the pattern emerge, later the mechanical interaction of the cells with the substratum stretches the network. Mathematical models in the relevant literature have been focusing just on either of the aspects of this complex system. In this paper, a unified view of the morphogenetic process is provided in terms of physical mechanisms and mathematical modeling.
Certain notions concerning physical frames
thought as geometrical support of
continuous systems are discussed; from these notions, independently from the continuum dynamics, the Cauchy problem for the
first order characteristics of the frame, as well as the associated (involutive) compatibility conditions,
involving only the initial data, are considered.
In [M. Pedicini and F. Quaglia. A parallel implementation for optimal lambda-calculus reduction PPDP '00: Proceedings of the 2nd ACM SIGPLAN international conference on Principles and practice of declarative programming, pages 314, ACM, 2000, M. Pedicini and F. Quaglia. PELCR: Parallel environment for optimal lambda-calculus reduction. CoRR, cs.LO/0407055, accepted for publication on TOCL, ACM, 2005], PELCR has been introduced as an implementation derived from the Geometry of Interaction in order to perform virtual reduction on parallel/distributed computing systems.
In this paper we provide an extension of PELCR with computational effects based on directed virtual reduction [V. Danos, M. Pedicini, and L. Regnier. Directed virtual reductions. In M. Bezem D. van Dalen, editor, LNCS 1258, pages 7688. EACSL, Springer Verlag, 1997], namely a restriction of virtual reduction [V. Danos and L. Regnier. Local and asynchronous beta-reduction (an analysis of Girard's EX-formula). LICS, pages 296306. IEEE Computer Society Press, 1993], which is a particular way to compute the Geometry of Interaction [J.-Y. Girard. Geometry of interaction 1: Interpretation of system F. In R. Ferro, et al. editors Logic Colloquium '88, pages 221260. North-Holland, 1989] in analogy with Lamping's optimal reduction [J. Lamping. An algorithm for optimal lambda calculus reduction. In Proc. of 17th Annual ACM Symposium on Principles of Programming Languages. ACM, San Francisco, California, pages 1630, 1990]. Moreover, the proposed solution preserves scalability of the parallelism arising from local and asynchronous reduction as studied in [M. Pedicini and F. Quaglia. PELCR: Parallel environment for optimal lambda-calculus reduction. CoRR, cs.LO/0407055, accepted for publication on TOCL, ACM, 2005].
