This contribution outlines current research aimed at developing models for personalized type 2 diabetes mellitus (T2D) prevention in the framework of the European project PRAESIIDIUM (Physics Informed Machine Learn-ing-Based Prediction and Reversion of Impaired Fasting Glucose Management) aimed at building a digital twin for preventing T2D in patients at risk. Specifically, the modelling approaches include both a multiscale, hybrid computational model of the human metaflammatory (metabolic and inflammatory) status, and data-driven models of the risk of developing T2D able to generate personalized recommendations for mitigating the individ-ual risk. The prediction algorithm will draw on a rich set of information for training, derived from prior clinical data, the individual's family history, and prospective clinical trials including clinical variables, wearable sensors, and a tracking mobile app (for diet, physical activity, and lifestyle). The models developed within the project will be the basis for building a platform for healthcare professionals and patients to estimate and monitor the indi-vidual risk of T2D in real time, thus potentially supporting personalized prevention and patient engagement.
