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2023 Contributo in volume (Capitolo o Saggio) restricted access

Merging On-chip and In-silico Modelling for Improved Understanding of Complex Biological Systems

Francesca Romana Bertani ; Gabriella Bretti ; Luca Businaro ; Adele De Ninno ; Annamaria Gerardino ; Roberto Natalini

In recent years an increasing interest is registered in the direction of developing techniques to combine experimental data and mathematical models, in order to produce systems, i.e., in silico models, whose solutions could reproduce and predict experimental outcomes. Indeed, the success of informed models is mainly due to the consistent improvements in computational abilities of the machines and in imaging techniques that allow a wider access to high spatial and temporal resolution data. Here we present an interdisciplinary work in the framework of Organs-on-chip (OoC) technology, and, more precisely, in Canceron-Chip (CoC) technology.

mathematical models cancer-on-chip numerical algorithms biomedical applications parameter estimation

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